Bulgarian Journal of Psychiatry, 2020; 5(1):8-16
COGNITIVE IMPAIRMENT IN PATIENTS WITH BIPOLAR AFFECTIVE DISORDER, SCHIZOPHRENIA AND THEIR RELATIVES – ENDOPHENOTYPE AND PREDIC-TIVE VALUE
Mladen Penchev1, Vihra Milanova2
1Department of Psychiatry and Medical Psychology, Medical University – Sofia
2Psychiatry Clinic, University Hospital “Alexandrovska” – Sofia
Abstract. In the current study, cognitive impairments in patients with bipolar affective disorder (BAD), schizophrenia and their relatives are discussed. The results of the neurocognitive tests, done by the patients with both disorders (BAD and schizophrenia) and their first and second degree relatives, are compared and the results of the three groups (patients with schizophrenia, patients with BAD and relatives of the patients with schizophrenia and BAD) are compared with the results of healthy controls. The average high school grade of the investigated participants is also compared. Disturbances in both groups of patients compared to controls are established. In our sample, patients with schizophrenia are more impaired than patients with BAD. The relatives of both groups of patients, have lower results on the neurocognitive tests than healthy controls. Both groups of patients and their relatives have lower average high school grades compared to controls.
Key words: cognitive impairment, bipolar disorder, schizophrenia, relatives, endophenotype
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