Abstract. Neurological soft signs (NSS) refer to subtle neurological abnormalities observed in several psychiatric disorders. NSS comprise deficits in sensory integration, motor coordination, and sequencing of complex motor acts. It has been proved that NSS are more prominent in schizophrenia. To a lesser extent, they are also identified in healthy people, which could be interpreted as a neurodevelopmental variation. Their occurrence is independent of the socio-demographic variables but they are more prevalent in cases with family history of psychоsis. Apart from schizophrenia, schizotypy and predisposition to auditory verbal hallucinations also modulate the manifestation of NSS. NSS, alone or in combination with other neurobiological markers, are potential candidates for endophenotype of schizophrenia.

Key words: schizophrenia, neurological soft signs

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