Abstract. Some psychiatric and cardiac diseases have extremely high incidence and morbidity, and comorbidities between diseases in these groups are often observed. For this reason, psychotropic and cardiovascular medications are widely used in clinical practice, and their co-administration is often required. This necessitates knowledge of drug interactions between these groups of medications in order to prevent the occurrence of clinically significant, including life-threatening, side effects, as well as to avoid the mutual reduction of the efficacy of the medicaments. Among the cardiovascular medications, anticoagulants and antiarrhythmic drugs deserve particular attention because of the frequent and dangerous drug interactions, in which they participate. Drug interactions between psychotropic drugs, anticoagulants and antiarrhythmic drugs are carried out by various mechanisms, the most common of which proceeds via the cytochrome P monooxygenase enzyme system. Because of the variety and frequency of interactions, acute clinical attention is needed when they are co-administered.

Key words: drug interactions, psychotropic medications, anticoagulants, antiarrythmic medications

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